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Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis

AuthorsPérez Rodríguez, María L.; Gómara Elena, María José ; Ercilla, Guadalupe; Sanmartí, Raimon; Haro Villar, Isabel
KeywordsRA diagnosis
Citrullinated peptides
Fibrinogen peptides
Rheumatoid arthritis
Issue Date23-Jun-2007
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 50(15): 3573-3584 (2007)
AbstractSince aggressive therapy given early in the rheumatoid arthritis (RA) disease course has the greatest therapeutic potential, early diagnostic tests with both high specificity and sensitivity are desirable. Rheumatoid sera were found to contain antibodies against citrullinated peptides, which are considered to be highly specific markers of RA. In the present work several analogues of the α- and β-chains of fibrin peptides containing different degrees of citrullination have been synthesized and analyzed by ELISA using 111 sera from RA patients. In addition, we have also investigated the synergistic effects of different presentation formats of the synthetic constructs. We have designed chimeric and cyclic peptides that bear different peptide sequences within the same molecule. Our results indicate that the synthesis of peptides bearing fibrinogen and filaggrin domains could be a robust method for the design of useful diagnostic strategies in RA.
Description12 pages, 9 figures.-- PMID: 17585853 [PubMed].-- Printed version published on Jul 26, 2007.-- Supplementary information (figs. S1-S7, tables S1-S2, 25 pages) available at: http://pubs.acs.org/doi/suppl/10.1021/jm0701932/suppl_file/jm0701932si20070529_011932.pdf
Publisher version (URL)http://dx.doi.org/10.1021/jm0701932
Appears in Collections:(IQAC) Artículos
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