Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/97169
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans |
Autor: | Álvarez, Carmen P.; Lasala, Fátima; Carrillo, Jaime CSIC; Muñiz, Óscar; Corbí, Angel L. ; Delgado, Rafael | Fecha de publicación: | jul-2002 | Editor: | American Society for Microbiology | Citación: | J. Virol. 76(13) 6841-6844 (2002) | Resumen: | Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection | Descripción: | 4 p.-3 fig. | Versión del editor: | http://dx.doi.org/10.1128/JVI.76.13.6841-6844.2002 | URI: | http://hdl.handle.net/10261/97169 | DOI: | 10.1128/JVI.76.13.6841-6844.2002. | ISSN: | 0022-538X |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
restringido.pdf | 20,73 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
381
checked on 28-mar-2024
Download(s)
182
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.