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Title

Interaction of vitamin D with membrane-based signaling pathways

AuthorsLarriba, María Jesús ; González-Sancho, José Manuel ; Bonilla, Félix; Muñoz Terol, Alberto
Keywords1α,25(OH)2D3
VDR
Membrane-based signaling
Wnt
Growth factors
Cytokines
Issue DateFeb-2014
PublisherFrontiers Media
CitationFrontiers in Physiology 5: 60 (2014)
AbstractMany studies in different biological systems have revealed that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) modulates signaling pathways triggered at the plasma membrane by agents such as Wnt, transforming growth factor (TGF)-β, epidermal growth factor (EGF), and others. In addition, 1α,25(OH)2D3 may affect gene expression by paracrine mechanisms that involve the regulation of cytokine or growth factor secretion by neighboring cells. Moreover, post-transcriptional and post-translational effects of 1α,25(OH)2D3 add to or overlap with its classical modulation of gene transcription rate. Together, these findings show that vitamin D receptor (VDR) cannot be considered only as a nuclear-acting, ligand-modulated transcription factor that binds to and controls the transcription of target genes. Instead, available data support the view that much of the complex biological activity of 1α,25(OH)2D3 resides in its capacity to interact with membrane-based signaling pathways and to modulate the expression and secretion of paracrine factors. Therefore, we propose that future research in the vitamin D field should focus on the interplay between 1α,25(OH)2D3 and agents that act at the plasma membrane, and on the analysis of intercellular communication. Global analyses such as RNA-Seq, transcriptomic arrays, and genome-wide ChIP are expected to dissect the interactions at the gene and molecular levels.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.3389/fphys.2014.00060
URIhttp://hdl.handle.net/10261/96709
DOI10.3389/fphys.2014.00060
ISSN1664-042X
Appears in Collections:(IIBM) Artículos
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