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dc.contributor.authorBlanco Rojo, R.-
dc.contributor.authorToxqui, Laura-
dc.contributor.authorLópez-Parra, A. M.-
dc.contributor.authorBaeza-Richer, Carlos-
dc.contributor.authorPérez Granados, Ana M.-
dc.contributor.authorArroyo Pardo, E.-
dc.contributor.authorVaquero, M. Pilar-
dc.identifierdoi: 10.3390/ijms15034077-
dc.identifierissn: 1422-0067-
dc.identifier.citationInternational Journal of Molecular Sciences 15: 4077- 4087 (2014)-
dc.description.abstractThe aim of this study was to investigate the combined influence of diet, menstruation and genetic factors on iron status in Spanish menstruating women (n = 142). Dietary intake was assessed by a 72-h detailed dietary report and menstrual blood loss by a questionnaire, to determine a Menstrual Blood Loss Coefficient (MBLC). Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs1375515 (CACNA2D3 gene); and rs1800562 and rs1799945 (HFE gene, mutations C282Y and H63D, respectively). Iron biomarkers were determined and cluster analysis was performed. Differences among clusters in dietary intake, menstrual blood loss parameters and genotype frequencies distribution were studied. A categorical regression was performed to identify factors associated with cluster belonging. Three clusters were identified: women with poor iron status close to developing iron deficiency anemia (Cluster 1, n = 26); women with mild iron deficiency (Cluster 2, n = 59) and women with normal iron status (Cluster 3, n = 57). Three independent factors, red meat consumption, MBLC and mutation C282Y, were included in the model that better explained cluster belonging (R2 = 0.142, p < 0.001). In conclusion, the combination of high red meat consumption, low menstrual blood loss and the HFE C282Y mutation may protect from iron deficiency in women of childbearing age. These findings could be useful to implement adequate strategies to prevent iron deficiency anemia. © 2014 by the authors; licensee MDPI, Basel, Switzerland.-
dc.description.sponsorshipThis study was supported by Project AGL2009-11437.We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.subjectMenstrual blood loss-
dc.subjectRed meat consumption-
dc.subjectHFE gene-
dc.subjectMenstruating women-
dc.subjectIron deficiency-
dc.titleInfluence of diet, menstruation and genetic factors on iron status: A cross-sectional study in Spanish women of childbearing age-
dc.description.versionPeer Reviewed-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
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