English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/95795
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

AuthorsSánchez-Mut, José V.; Aso, Esther; Panayotis, Nicolás; Lott, Ira; Dierssen, M.; Rábano, Alberto; Urdinguio, Rocío G.; Fernández, Agustín F.; Astudillo, Aurora; Martín-Subero, José Ignacio; Balint, Balazs; Fraga, Mario F.; Gómez, Antonio; Gurnot, Cecile; Roux, Jean- Christophe; Ávila, Jesús ; Hensch, Takao K.; Ferrer, Isidro; Esteller, Manel
KeywordsAlzheimer’s disease
Brain regions
DNA methylation
Issue Date2013
PublisherOxford University Press
CitationBrain, a journal of neurology 136: 3018- 3027 (2013)
AbstractThe central nervous system has a pattern of gene expression that is closely regulated with respect to functional and anatomical regions. DNA methylation is a major regulator of transcriptional activity, and aberrations in the distribution of this epigenetic mark may be involved in many neurological disorders, such as Alzheimer's disease. Herein, we have analysed 12 distinct mouse brain regions according to their CpG 5'-end gene methylation patterns and observed their unique epigenetic landscapes. The DNA methylomes obtained from the cerebral cortex were used to identify aberrant DNA methylation changes that occurred in two mouse models of Alzheimer's disease. We were able to translate these findings to patients with Alzheimer's disease, identifying DNA methylation-associated silencing of three targets genes: thromboxane A2 receptor (TBXA2R), sorbin and SH3 domain containing 3 (SORBS3) and spectrin beta 4 (SPTBN4). These hypermethylation targets indicate that the cyclic AMP response element-binding protein (CREB) activation pathway and the axon initial segment could contribute to the disease. © 2013 The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
Identifiersdoi: 10.1093/brain/awt237
issn: 0006-8950
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.