English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/95714
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Concerted expression of the thermogenic and bioenergetic mitochondrial protein machinery in brown adipose tissue

AuthorsGuillén, Carlos; Bartolomé, Alberto; Vila-Bedmar, Rocío ; García-Aguilar, Ana; Gómez-Hernández, Almudena; Benito, Manuel
ATP synthase
Mitochondrial bioenergetics
Brown adipose tissue
Issue Date2013
PublisherJohn Wiley & Sons
CitationJournal of Cellular Biochemistry 114: 2306- 2313 (2013)
AbstractBrown adipose tissue (BAT) is specialized in non-shivering thermogenesis through the expression of the mitochondrial uncoupling protein-1 (UCP1). In this paper, we describe the relationship between UCP1 and proteins involved in ATP synthesis. By the use of BATIRKO mice, which have enhanced UCP1 expression in BAT, an increase in ATP synthase as well as in ubiquinol cytochrome c reductase levels was observed. Alterations in mitochondrial mass or variations in ATP levels were not observed in BAT of these mice. In addition, using a protocol of brown adipocyte differentiation, the concerted expression of UCP1 with ATP synthase was found. These two scenarios revealed that increases in the uncoupling machinery of brown adypocites must be concomitantly followed by an enhancement of proteins involved in ATP synthesis. These concerted changes reflect the need to maintain ATP production in an essentially uncoupling cell type. J. Cell. Biochem. 114: 2306-2313, 2013. © 2013 Wiley Periodicals, Inc. Copyright © 2013 Wiley Periodicals, Inc.
Identifiersdoi: 10.1002/jcb.24577
issn: 0730-2312
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.