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Modulation of leukocytic populations of gilthead sea bream (Sparus aurata) by the intestinal parasite Enteromyxum leei (Myxozoa: Myxosporea)

AuthorsEstensoro, Itziar ; Mulero, Iván; Redondo, Mª José ; Álvarez-Pellitero, Mª del Pilar ; Mulero, Victoriano; Sitjà-Bobadilla, Ariadna
Gut associated lymphoid tissue
Eosinophilic granular cells
Mast cells
Acidophilic granulocytes
Lymphohaematopoietic organs
Mucosal infection
Plasma cells
Issue DateMar-2014
PublisherCambridge University Press
CitationParasitology 141(3): 425-440 (2014)
AbstractThe cellular mucosal and systemic effectors of gilthead sea bream (GSB) (Sparus aurata) involved in the acute immune response to the intestinal parasite Enteromyxum leei were studied in fish experimentally infected by the anal route. In the intestinal inflammatory infiltrates and in lymphohaematopoietic organs (head kidney and spleen) of parasitized fish, the number of plasma cells, B cells (IgM immunoreactive) and mast cells (histamine immunoreactive) were significantly higher, whereas the number of acidophilic granulocytes (G7 immunoreactive) decreased, compared with non-parasitized and unexposed fish. These differences were stronger at the posterior intestine, the main target of the parasite, and no differences were found in the thymus. In non-parasitized GSB, the percentage of splenic surface occupied by melanomacrophage centres was significantly higher. These results suggest that the cellular response of GSB to E. leei includes proliferation of leukocytes in lymphohaematopoietic organs and recruitment into intestines via blood circulation involving elements of innate and adaptive immunity. Acidophilic granulocytes and mast cells presented opposite patterns of response to the parasite infection, with an overall depletion of the former and an increased amount of the latter. Some differences between both cell types were also detected in regard to their granule density and cell morphology. © Cambridge University Press 2013.
Identifiersdoi: 10.1017/S0031182013001789
issn: 0031-1820
Appears in Collections:(IATS) Artículos
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