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dc.contributor.authorEgido-Gabás, Meritxell-
dc.contributor.authorCanals, Daniel-
dc.contributor.authorCasas, Josefina-
dc.contributor.authorLlebaria, Amadeu-
dc.contributor.authorDelgado Cirilo, Antonio-
dc.date.accessioned2009-01-09T13:34:16Z-
dc.date.available2009-01-09T13:34:16Z-
dc.date.issued2007-05-04-
dc.identifier.citationChemMedChem 2(7): 992-994 (2007)en_US
dc.identifier.issn1860-7179-
dc.identifier.urihttp://hdl.handle.net/10261/9515-
dc.description3 pages, 4 figures.-- PMID: 17479993 [PubMed].-- Supporting information (11 pages) available at: http://www.wiley-vch.de/contents/jc_2452/2007/z700061_s.pdfen_US
dc.descriptionPrinted version published on Jul 7, 2007.-
dc.description.abstractSome genetic pathologies are associated to mutations that produce minor changes in a protein structure. Further studies to improve cell tolerance, disclose the key structural motifs required for the chaperone activity, and confer selectivity against different point mutations of the defective enzyme are currently underway in our group and will be reported in due course.en_US
dc.description.sponsorshipPartial financial support from the Ministerio de Ciencia y Tecnología (Spain) (Project MCYT CTQ2005-00175/BQU), Fondos Feder (EU), the Ministerio de Sanidad y Consumo (Spain) (Project PIO40767), and CSIC (Projects PIF 2004-80F026) is acknowledged. We are also grateful to Genzyme for a generous donation of Imiglucerase (CerezymeK).en_US
dc.format.extent162 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoengen_US
dc.publisherJohn Wiley & Sonsen_US
dc.rightsclosedAccessen_US
dc.subjectChaperonesen_US
dc.subjectCyclitolsen_US
dc.subjectGaucheren_US
dc.subjectGlycolipidsen_US
dc.subjectGlucocerebrosidaseen_US
dc.titleAminocyclitols as Pharmacological Chaperones for Glucocerebrosidase, a Defective Enzyme in Gaucher Diseaseen_US
dc.typeartículoen_US
dc.identifier.doi10.1002/cmdc.200700061-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1002/cmdc.200700061en_US
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