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Chemical interrogation of drug/RNA complexes: From chemical reactivity to drug design

AuthorsJiménez-Moreno, Ester; Gomez-Pinto, Irene ; Corzana, Francisco; Santana, Andrés G. ; Revuelta, Julia ; Bastida, Agatha; Jiménez-Barbero, Jesús ; González, Carlos ; Asensio, Juan Luis
KeywordsAminoglycoside/RNA complexes
Combinatorial chemistry
Drug design
NMR spectroscopy
Issue Date2013
PublisherJohn Wiley & Sons
CitationAngewandte Chemie - International Edition 52: 3148- 3151 (2013)
AbstractWhen you're in a (RNA) bind: An NMR-based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Identifiersdoi: 10.1002/anie.201209434
issn: 1433-7851
e-issn: 1521-3773
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