Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/93610
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women |
Autor: | Toxqui, Laura CSIC ORCID; Pérez Granados, Ana M. CSIC; Blanco-Rojo, Ruth CSIC ORCID; Wright, Ione CSIC; Piedra, Concepción de la; Vaquero, M. Pilar CSIC ORCID ; Vaquero, M. Pilar CSIC ORCID | Palabras clave: | 25-hydroxyvitamin D Bone turnover markers Menstruating women Iron deficiency Fortified food Vitamin D deficiency |
Fecha de publicación: | 2014 | Editor: | Springer Nature | Citación: | European Journal of Nutrition 53: 441- 448 (2014) | Resumen: | Purpose: This study aimed to determine whether there is a relationship between iron status and bone metabolism, and to compare the effects of the consumption, as part of the usual diet, of an iron or iron and vitamin D-fortified skimmed milk on bone remodelling in iron-deficient women. Methods: Young healthy iron-deficient or iron-sufficient women (serum ferritin ≤30 ng/mL or >30 ng/mL, respectively) were recruited. Iron-deficient women were assigned to a nutritional intervention consisting of a randomised, controlled, double-blind, parallel design trial of 16 weeks during winter. They consumed, as part of their usual diet, an iron (Fe group, n = 54) or iron and vitamin D-fortified (Fe+D group, n = 55) flavoured skimmed milk (iron, 15 mg/day; vitamin D3, 5 μg/day, 200 IU). The iron-sufficient women followed their usual diet without supplementation (R group, n = 56). Dietary intake, body weight, iron biomarkers, 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), procollagen-type 1 N-terminal propeptide (P1NP), and aminoterminal telopeptide of collagen I (NTx) were determined. Results: Negative correlations were found between baseline log-ferritin and log-NTx (p < 0.001), and between transferrin and P1NP (p = 0.002). Serum 25OHD increased (from 62 ± 21 to 71 ± 21 nmol/L, mean ± SD, p < 0.001) while P1NP and NTx decreased in Fe+D during the assay (p = 0.004 and p < 0.001, respectively). NTx was lower in Fe+D compared to Fe at week 8 (p < 0.05) and was higher in Fe and Fe+D compared to R throughout the assay (p < 0.01). PTH did not show changes. Conclusions: Iron deficiency is related with higher bone resorption in young women. Consumption of a dairy product that supplies 5 μg/day of vitamin D3 reduces bone turnover and increases circulating 25OHD to nearly reach an optimal vitamin D status, defined as 25OHD over 75 nmol/L. © 2013 Springer-Verlag Berlin Heidelberg. | URI: | http://hdl.handle.net/10261/93610 | DOI: | 10.1007/s00394-013-0544-4 | Identificadores: | doi: 10.1007/s00394-013-0544-4 issn: 1436-6207 |
Aparece en las colecciones: | (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
36
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
35
checked on 17-feb-2024
Page view(s)
368
checked on 21-abr-2024
Download(s)
284
checked on 21-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.