Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/93313
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Antithrombin activity and outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass

AutorMuedra, Vicente; Barettino, Domingo CSIC; D’Ocón, Pilar; Zuñiga, Angel; Moreno, Lucrecia
Palabras claveAntithrombin
Cardiopulmonary bypass
Extracorporeal circulation
Fecha de publicación1-jun-2013
EditorLippincott Williams & Wilkins
CitaciónBlood Coagulation and Fibrinolysis 24(4):454-7 (2013)
ResumenBackground: We recently reported prospective results from a cohort of patients scheduled for elective cardiac surgery with cardiopulmonary bypass (CPB) in which most baseline clinical parameters of patients and surgery outcomes failed to demonstrate relationships with post-CPB antithrombin (AT) activity. Objective and Methods: In this extension study, a larger sample size (250 patients) was analyzed following general linear models. Patients’ demographic and pre-CPB clinical data as well as pre/post-CPB AT activity and outcomes were collected. Results: There was a significant decrease of post-CPB AT activity (95.6±13.7% to 64.6±12.1%; p<0.001). Univariate and multivariate analyses revealed that a decrease of ~1% post-CPB AT activity may be expected per 3 years increase in patient’s age. Univariate analysis showed that post-CBP AT activity was inversely related to the need for transfusions,acute renal failure and occurrence of any complication (re-intervention, low cardiac output,arrhythmia, lung dysfunction, stroke, acute renal failure, mesenteric ischemia and re-hospitalization; P<0.05). Multivariate analysis adjusted for age and pre-CPB AT did not show statistical significance. Odds ratio (OR) <1 was observed in most outcomes (0.8 in average), which suggested a reduction of the probability for an increase of 10% in post-CBP AT. Conclusions: Our results confirm the role of low postsurgery AT activity influencing outcomes in patients undergoing CPB.
Descripción14 páginas, 1 figura, 1 tabla
Versión del editorhttp://dx.doi.org/10.1097/MBC.0b013e32835d5422
URIhttp://hdl.handle.net/10261/93313
DOI10.1097/MBC.0b013e32835d5422
ISSN0957-5235
E-ISSN1473-5733
Aparece en las colecciones: (IBV) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
2013 Blood Coagulation & Fibrinolysis.pdf225,26 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

11
checked on 27-mar-2024

WEB OF SCIENCETM
Citations

10
checked on 24-feb-2024

Page view(s)

417
checked on 28-mar-2024

Download(s)

419
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.