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MicroRNA precursors are not structurally robust but plastic

AuthorsRodrigo, Guillermo ; Elena, Santiago F.
Keywordsconformational flexibility
non-coding RNA
secondary structure
Issue Date8-Dec-2012
PublisherOxford University Press
CitationGenome biology and evolution 5(1): 181-186 (2012)
AbstractRobustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate nullmodel. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs. © 2012 The Author(s).
Publisher version (URL)https://doi.org/10.1093/gbe/evs132
Appears in Collections:(IBMCP) Artículos
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