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Title

Chimeric polypeptides derived from the vimentin protein, suitable for use in the diagnosis of rheumatoid arthritis

Other TitlesPolipeptidos quiméricos derivados de la proteina vimentina con utilidad para el diagnostico de la artritis reumatoide
AuthorsHaro Villar, Isabel; Gómara Elena, María José; Sanmartí, Raimon
Issue Date31-Jan-2013
CitationWO2013014312 A1
Abstract[EN] The invention relates to chimeric polypeptides derived from the vimentin protein, which can detect the antibodies generated in rheumatoid arthritis (RA), comprising at least two citrullinated peptide subunits from: (i) a citrullinated peptide subunit from vimentin, (ii) a citrullinated peptide subunit from the a chain of fibrin and (iii) a citrullinated peptide subunit from filaggrin. In addition, the invention also relates to an antigenic composition, a method and kit for the diagnosis of rheumatoid arthritis based on the detection of the auto-antibodies generated over the course of the disease.
[ES] La presente invención se refiere a polipéptidos quiméricos derivados de la proteina vimentina, capaces de detectar los anticuerpos generados en la artritis reumatoide (AR), que comprenden al menos dos subunidades peptidicas citrulinadas de entre las siguientes: (i) una procedente de la vimentina, (ii) una procedente de la cadena alfa de la fibrina y (iii) una procedente de la filagrina. Además, la inversión comprende una composición antigénica, un método y un kit para el diagnóstico de la artritis reumatoide, a partir de la detección de los auto-anticuerpos generados durante el curso de dicha enfermedad.
URIhttp://hdl.handle.net/10261/92550
Appears in Collections:(IQAC) Patentes
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