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Cardiotrophin-1 (CT-1) plays a key role in enhancing antiapoptotic defenses and maintaining mitochondrial function during liver regeneration

AuthorsMartínez, Emili ; Morales, Albert ; Fernández-Checa, José C. ; Prieto Valtueña, J.
Issue DateApr-2013
CitationJournal of Hepatology 58(Supl.1): S131 (2013)
Abstract[Background and Aims]: Following partial hepatectomy (PH) the liver exhibits increased resistance against hepatocellular damaging agents but the mechanisms remain poorly characterised. Here, we evaluated the role of endogenous CT-1 (a potent cytoprotective cytokine) in the defence of the regenerating liver against proapoptotic insults. Since mitochondria participate in the process of cell death, we analyzed mitochondrial function in CT-1 null mice and wild type (wt) controls post-PH. [Results]: We detected increased CT-1 protein levels in serum and liver 24h after PH. At this time point serum AST and bilirubin levels were higher in CT-1 KO than in wt. We observed that Stat3 was activated 1h post-PH in wt but not in CT-1 null mice and that the anti-apoptotic gene IGFB1 was upregulated 3h post-PH at significantly higher levels in wt than in CT-1 KO. A significant elevation of the cytoprotective molecule sphingosine-1 phosphate (S1P) was found at 5 h post-PH in wt but not in CT-1 null mice. Also, sphingosine kinase 1 (SPHK1) was upregulated at 3h post-PH in wt and significantly less in CT-1 KO. In wt mice the administration of Jo2 caused less necroapoptosis in PH mice than in sham animals. However the opposite was observed in CT-1 null mice. These animals showed impaired regenarative response, compared to wt, when Jo2 was given 24h after PH. Moreover, in CT-1 KO mice mitochondrial function was impaired following PH more markedly than in wt mice and this alteration was aggravated after Jo2 challenge. [Conclusions]: During liver regeneration CT-1 is essential for upgrading antiapoptotic defences and maintaining mitochondrial function. CT-1 appears to be crucial for regeneration of damaged livers.
DescriptionResumen del póster presentado a The International Liver Congress – 48th Annual meeting of the European Association for the Study of the Liver celebrado en Paises Bajos en abril de 2013.-- et al.
Publisher version (URL)http://dx.doi.org/10.1016/S0168-8278(13)60315-3
Identifiersdoi: 10.1016/S0168-8278(13)60315-3
issn: 0168-8278
e-issn: 1600-0641
Appears in Collections:(IIBB) Artículos
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