Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/92114
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon

AutorMartínez Valladares, María CSIC ORCID CVN ; Cordero Pérez, M.; Rojo Vázquez, Francisco Antonio CSIC ORCID
Palabras claveAlbendazole
Anthelmintic resistance
Clorsulon
Drug combination
Fasciola hepatica
Sheep
Fecha de publicaciónene-2014
EditorElsevier
CitaciónExperimental Parasitology 136(1) : 59-62 (2014)
ResumenIn the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anthelmintics, namely albendazole (ABZ), triclabendazole (TCBZ) and clorsulon (CLOR). The identification of one flock resistant to ABZ and CLOR was shown after the faecal egg count reduction test (FECRT). The reductions in eggs per gram values were -17.6% and -68% against immature and adult flukes, respectively, after ABZ treatment; 85.15% and 44.91% against immature and adult flukes, respectively, after CLOR treatment; and 97.06% against both stages, after the administration of TCBZ. As an alternative to control the infection, two combinations of ABZ and CLOR were tested. In the first, both drugs were administered at the recommended dose of each; in this case, the efficiency reached values above 95% against both immature and adult flukes. However, when the combined drugs were administered at half the recommended dose of each, the efficiency of the combination was very low, i.e. 16.67% and -11.11% against mature and immature flukes, respectively. In conclusion, this preliminary report suggests a possible interaction between ABZ and CLOR after their joint administration. However, these results should be confirmed in other flocks.
Descripción4 páginas.
Versión del editorhttp://dx.doi.org/10.1016/j.exppara.2013.10.010
URIhttp://hdl.handle.net/10261/92114
DOI10.1016/j.exppara.2013.10.010
ISSN0014-4894
Aparece en las colecciones: (IGM) Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Embargo. Digital.CSIC..pdf21,67 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

31
checked on 22-mar-2024

WEB OF SCIENCETM
Citations

26
checked on 25-feb-2024

Page view(s)

309
checked on 29-mar-2024

Download(s)

298
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.