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Title

Significant differences in coeliac immunotoxicity of barley varieties

AuthorsComino, Isabel; Gil Humanes, Javier ; Pistón, Fernando ; Lorenzo, Laura de; Barro Losada, Francisco ; Sousa Martín, Carolina
KeywordsCoeliac disease
33-mer
Interferon-gamma
Monoclonal antibody
Barley
Issue DateNov-2012
PublisherWiley-VCH
CitationMolecular Nutrition and Food Research 56(11): 1697-1707 (2012)
AbstractScope: The only treatment available for coeliac disease (CD) is a strict diet in which the intake of wheat, barley, rye, or oats is avoided. Barley is a major cereal crop, grown mainly for its use in brewing, and it has high nutritional value. The identification of varieties with a reduced toxicity profile may contribute to improve the diet, the quality of life and health of CD patients. Methods and results: Searching for harmless barleys, we investigated accessions of malting and wild barley, used for developing new cultivated cereals. The CD toxicity profile of barleys was screened using G12 antibody and cell proliferation and IFN-γ release from peripheral blood mononuclear cells and intestinal biopsies from CD patients. We found a direct correlation between the reactivity with G12 and the immunogenicity of the different barleys. Conclusion: The malting barleys were less immunogenic, with reduced levels of toxic gluten, and were possibly less harmful to CD patients. Our findings could raise the prospect of breeding barley species with low levels of harmful gluten, and the attractive goal of developing nontoxic barley cultivars, always taking into account the Codex standard for foods for special dietary use for persons intolerant to gluten. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URIhttp://hdl.handle.net/10261/92050
DOI10.1002/mnfr.201200358
Identifiersdoi: 10.1002/mnfr.201200358
issn: 1613-4125
e-issn: 1613-4133
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