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A prototype of very high-resolution small animal PET scanner using silicon pad detectors

AuthorsPark, Sang-June; Rogers, W. Leslie; Huh, Sam; Kagan, Harris; Honscheid, Klaus; Burdette, Don; Chesi, Enrico; Lacasta Llácer, Carlos ; Llosá, Gabriela ; Mikuz, Marko; Studen, Andrej; Weilhammer, Peter; Clinthorne, Neal H.
KeywordsCompton camera
Performance evaluation
Micropet scanner
Very high resolution
Positron emission tomograph (PET)
Silicon pad detector
Issue Date21-Jan-2007
CitationNuclear Instruments & Methods in Physics Research Section A - Accelerators, Spectrometers, Detectors and Associated Equipment 570(3): 543-555 (2007)
AbstractA very high-resolution small animal positron emission tomograph (PET), which can achieve sub-millimeter spatial resolution, is being developed using silicon pad detectors. The prototype PET for a single slice instrument consists of two I mm thick silicon pad detectors, each containing a 32 x 16 array of 1.4 x 1.4 mm pads readout with four VATAGP3 chips which have 128 channels low-noise self-triggering ASIC in each chip, coincidence units, a source turntable and tungsten slice collimator. The silicon detectors were located edgewise on opposite sides of a 4cm field-of-view to maximize efficiency. Energy resolution is dominated by electronic noise, which is 0.98% (1.38 keV) FWHM at 140.5 keV. Coincidence timing resolution is 82.1 ns FWHM and coincidence efficiency was measured to be 1.04 x 10(-3)% from two silicon detectors with annihilation photons of F-18 source. Image data were acquired and reconstructed using conventional 2-D filtered-back projection (FBP) and a maximum likelihood expectation maximization (ML-EM) method. Image resolution of approximately 1.45mm FWHM is obtained from 1-D profile of 1.1 mm diameter F-18 line source image. Even better resolution can be obtained with smaller detector element sizes. While many challenges remain in scaling up the instrument to useful efficiency including densely packed detectors and significantly improved timing resolution, performance of the test setup in terms of easily achieving sub-millimeter resolution is compelling. (c) 2006 Elsevier B.V. All rights reserved.
Description13 pages, 18 figures.-- PACS nr.: 87.58.Fg.-- PMID: 18084629 [PubMed].-- PMCID: PMC2140047.-- ISI Article Identifier: 000244137900022
Available online Nov 27, 2006.-- Paper available Open Access at NIH PubMed Central.
Publisher version (URL)http://dx.doi.org/10.1016/j.nima.2006.10.277
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