English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/89659
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Bone remodelling is reduced by recovery from iron-deficiency anaemia in premenopausal women

AuthorsWright, Ione ; Blanco Rojo, R. ; Fernández, Cristina; Toxqui, Laura ; Moreno, Gema; Pérez Granados, Ana M. ; Piedra, Concepción de la; Remacha, A. F.; Vaquero, M. Pilar
KeywordsVitaminD status
Bone resorption
Menstruating women
Bone turnover markers
Iron-deficiency anaemia
PTH
Issue Date2013
PublisherUniversidad de Navarra
CitationJournal of Physiology and Biochemistry 69: 889- 896 (2013)
AbstractIron-deficiency anaemia (IDA), one of the most common and widespread health disorders worldwide, affects fundamental metabolic functions and has been associated with deleterious effects on bone. Our aim was to know whether there are differences in bone remodelling between a group of premenopausal IDA women and a healthy group, and whether recovery of iron status has an effect on bone turnover markers. Thirty-five IDA women and 38 healthy women (control group) were recruited throughout the year. IDA women received pharmacological iron treatment. Iron biomarkers, aminoterminal telopeptide of collagen I (NTx), procollagen type 1 N-terminal propeptide (P1NP), 25-hydroxyvitamin D, and parathormone (PTH) were determined at baseline for both groups and after treatment with pharmacological iron for the IDA group. IDA subjects were classified as recovered (R) or non-recovered (nR) from IDA after treatment. NTx levels were significantly higher (p <0.001), and P1NP levels tended to be lower in IDA women than controls after adjusting for age and body mass index (BMI), with no differences in 25-hydroxyvitamin D or PTH. After treatment, the R group had significantly lower NTx and P1NP levels compared to baseline (p <0.05 and p <0.001 respectively), whilst no significant changes were seen in the nR group. No changes were seen in 25-hydroxyvitamin D or PTH for either group. IDA is related to higher bone resorption independent of age and BMI. Recovery from IDA has a concomitant beneficial effect on bone remodelling in premenopausal women, decreasing both bone resorption and formation. © 2013 University of Navarra.
URIhttp://hdl.handle.net/10261/89659
DOI10.1007/s13105-013-0266-3
Identifiersdoi: 10.1007/s13105-013-0266-3
issn: 1138-7548
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.