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http://hdl.handle.net/10261/88514
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dc.contributor.author | Martins Alho, Miriam A. | - |
dc.contributor.author | D’Accorso, Norma B. | - |
dc.contributor.author | Ochoa, Carmen | - |
dc.contributor.author | Castro, Ana | - |
dc.contributor.author | Calderón, Félix | - |
dc.contributor.author | Chana López, Antonio | - |
dc.contributor.author | Reviriego, Felipe | - |
dc.contributor.author | Páez, Juan A. | - |
dc.contributor.author | Campillo, Nuria E. | - |
dc.contributor.author | Martínez-Grueiro, Mercedes | - |
dc.contributor.author | López-Santa Cruz, Ana M. | - |
dc.contributor.author | Martínez, Antonio R. | - |
dc.date.accessioned | 2013-12-12T09:56:18Z | - |
dc.date.available | 2013-12-12T09:56:18Z | - |
dc.date.issued | 2004 | - |
dc.identifier | doi: 10.1016/j.bmc.2004.06.004 | - |
dc.identifier | issn: 0968-0896 | - |
dc.identifier | e-issn: 1464-3391 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry 12: 4431- 4437 (2004) | - |
dc.identifier.uri | http://hdl.handle.net/10261/88514 | - |
dc.description.abstract | 6,7-Diaryl derivatives of mono and di-S-glycopyranosylthiolumazine derivatives 5-8 were prepared to test their nematocide activity. In vitro tests against Caenorhabditis elegans were performed and it was found that monosubstituted derivatives 5-7 showed higher activity than the corresponding unsubstituted 2-thiolumazines 1-3, whilst 2-S,4-S-di-glycopyranosylpteridine derivative 8 was inactive in contrast to unsubstituted derivative 4. In order to check whether the lack of activity of 8 was due to the two bulky substituents of the pteridine nucleus, 2-S,4-S-dimethyl derivative 9 was synthesized and assayed showing also lack of activity. A theoretical study on the stability of the different possible tautomers of compound 4 was carried out in an attempt to explain some, in appearance, anomalous 13C NMR data of this compound. © 2004 Elsevier Ltd. All rights reserved. | - |
dc.language.iso | eng | - |
dc.publisher | Pergamon Press | - |
dc.rights | closedAccess | - |
dc.title | Synthesis and nematocide activity of S-glycopyranosyl-6,7- diarylthiolumazines | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.bmc.2004.06.004 | - |
dc.date.updated | 2013-12-12T09:56:18Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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