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Título: | GAGA factor repression of transcription is a rare event but the negative regulation of Trl is conserved in Drosophila species |
Autor: | Piñeyro, David CSIC ORCID; Blanch, Marta CSIC; Badal, Martí; Kosoy, Ana; Bernués, Jordi CSIC ORCID | Palabras clave: | Drosophila GAGA factor Mechanism of repression Regulation of transcription |
Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | BBA - Gene Regulatory Mechanisms1829(10): 1056-1065 (2013) | Resumen: | GAGA is a highly conserved Drosophila transcription factor encoded by the Trithorax-like (. Trl) gene. While GAGA usually activates transcription, it represses its own promoter. Here we show that GAGA-mediated repression of Trl is conserved between two distant Drosophila species. A detailed promoter study showed that GAGA repressive activity can't be attributed to any discrete element in the Trl promoter. Genome-wide analysis of the transcriptome in S2 cells indicated that repression of Trl is very likely unique, being GAGA factor a transactivator for all the other promoters. Taken together, our results suggest a new mechanism to explain GAGA-mediated repression that involves a dose-dependent change in the architecture of the Trl promoter. © 2013 Elsevier B.V. | URI: | http://hdl.handle.net/10261/88192 | DOI: | 10.1016/j.bbagrm.2013.07.002 | Identificadores: | doi: 10.1016/j.bbagrm.2013.07.002 issn: 1874-9399 |
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