Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/87875
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program |
Autor: | Estarás, Conchi CSIC ORCID; Akizu, Naiara; García, Alejandra; Beltrán, Sergi; Cruz, Xavier de la CSIC ORCID; Martínez-Balbás, Marian CSIC ORCID | Palabras clave: | Epigenetic regulation JMJD3 (Kdm6b) Smad3 TGFβ pathway Neurogenesis Histone demethylation |
Fecha de publicación: | 2012 | Editor: | Company of Biologists | Citación: | Development 139(15): 2681-2691 (2012) | Resumen: | Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed. | Versión del editor: | http://dx.doi.org/10.1242/dev.078345 | URI: | http://hdl.handle.net/10261/87875 | DOI: | 10.1242/dev.078345 | Identificadores: | doi: 10.1242/dev.078345 e-issn: 1477-9129 issn: 0950-1991 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Estaras.et al.2012.OP.pdf | 819,57 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
83
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
79
checked on 25-feb-2024
Page view(s)
316
checked on 21-abr-2024
Download(s)
253
checked on 21-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.