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Título: | Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles |
Autor: | Castro, Ana CSIC ORCID; Castaño, Tania; Encinas, Arantxa; Porcal, Williams; Gil, Carmen CSIC ORCID | Fecha de publicación: | 2006 | Editor: | Pergamon Press | Citación: | Bioorganic and Medicinal Chemistry 14: 1644- 1652 (2006) | Resumen: | Chemical properties of 1,2,4-thiadiazole have been reviewed in the last few years. However, the usefulness of 1,2,4-thiadiazole as a privileged system in medicinal chemistry has prompted the advances on the therapeutic potential of this system. This review provides a brief summary of the medicinal chemistry of 1,2,4-thiadiazole system and highlights some examples of 1,2,4-thiadiazole- containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 1,2,4-thiadiazole is presented in sections by generalized synthetic methods. © 2005 Elsevier Ltd. All rights reserved. | URI: | http://hdl.handle.net/10261/87161 | DOI: | 10.1016/j.bmc.2005.10.012 | Identificadores: | doi: 10.1016/j.bmc.2005.10.012 issn: 0968-0896 e-issn: 1464-3391 |
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