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Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles

AuthorsCastro, Ana ; Castaño, Tania; Encinas, Arantxa; Porcal, Williams; Gil, Carmen
Issue Date2006
PublisherPergamon Press
CitationBioorganic and Medicinal Chemistry 14: 1644- 1652 (2006)
AbstractChemical properties of 1,2,4-thiadiazole have been reviewed in the last few years. However, the usefulness of 1,2,4-thiadiazole as a privileged system in medicinal chemistry has prompted the advances on the therapeutic potential of this system. This review provides a brief summary of the medicinal chemistry of 1,2,4-thiadiazole system and highlights some examples of 1,2,4-thiadiazole- containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 1,2,4-thiadiazole is presented in sections by generalized synthetic methods. © 2005 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.bmc.2005.10.012
issn: 0968-0896
e-issn: 1464-3391
Appears in Collections:(IQM) Artículos
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