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Título

CentrosomeDB: a human centrosomal proteins database

AutorNogales-Cadenas, Rubén; Abascal, Federico ; Díez-Pérez, Javier; Carazo, José M.; Pascual-Montano, Alberto
Palabras claveHuman centrosome
Centrosomal proteins
Domain organization
Centrosomal genes
Orthology relationships
Fecha de publicación29-oct-2008
EditorOxford University Press
CitaciónNucleic Acids Research; doi: 10.1093/nar/gkn815 (2008)
ResumenActive research on the biology of the centrosome during the past decades has allowed the identification and characterization of many centrosomal proteins. Unfortunately, the accumulated data is still dispersed among heterogeneous sources of information. Here we present centrosome:db, which intends to compile and integrate relevant information related to the human centrosome. We have compiled a set of 383 likely human centrosomal genes and recorded the associated supporting evidences. Centrosome:db offers several perspectives to study the human centrosome including evolution, function and structure. The database contains information on the orthology relationships with other species, including fungi, nematodes, arthropods, urochordates and vertebrates. Predictions of the domain organization of centrosome:db proteins are graphically represented at different sections of the database, including sets of alternative protein isoforms, interacting proteins, groups of orthologs and the homologs identified with blast. Centrosome:db also contains information related to function, gene–disease associations, SNPs and the 3D structure of proteins. Apart from important differences in the coverage of the set of centrosomal genes, our database differentiates from other similar initiatives in the way information is treated and analyzed. Centrosome:db is publicly available at http://centrosome.dacya.ucm.es.
Descripción6 pages, 2 figures.-- PMID: 18971254 [PubMed].-- Open access paper at the publisher's site.-- Supplementary web site available at: http://centrosome. dacya.ucm.es/centrosome/supmat.
Versión del editorhttp://dx.doi.org/10.1093/nar/gkn815
URIhttp://hdl.handle.net/10261/8708
DOI10.1093/nar/gkn815
ISSN0305-1048
E-ISSN1362-4962
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