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The extradomain A of fibronectin (EDA) combined with poly(I: C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model

AuthorsSan Román, Beatriz ; Andrés, Ximena de ; Muñoz, Pilar M. ; Obregón, Patricia ; Asensio, Aaron C.; Garrido, Victoria ; Andrés, Damián F. de ; Amorena Zabalza, Beatriz ; Grilló, María Jesús
Issue Date28-Mar-2012
CitationVaccine 30(15): 2564-2569 (2012)
AbstractThe development of effective vaccines against HIV-1 infection constitutes one of the major challenges in viral immunology. One of the protein candidates in vaccination against this virus is p24, since it is a conserved HIV antigen that has cytotoxic and helper T cell epitopes as well as B cell epitopes that may jointly confer enhanced protection against infection when used in immunization-challenge approaches. In this context, the adjuvant effect of EDA (used as EDAp24 fusion protein) and poly(I:C), as agonists of TLR4 and TLR3, respectively, was assessed in p24 immunizations using a recombinant Listeria monocytogenes HIV-1 Gag proteins (Lm-Gag, where p24 is the major antigen) for challenge in mice. Immunization with EDAp24 fusion protein together with poly(I:C) adjuvant induced a specific p24 IFN-γ production (Th1 profile) as well as protection against a Lm-Gag challenge, suggesting an additive or synergistic effect between both adjuvants. The combination of EDA (as a fusion protein with the antigen, which may favor antigen targeting to dendritic cells through TLR4) and poly(I:C) could thus be a good adjuvant candidate to enhance the immune response against HIV-1 proteins and its use may open new ways in vaccine investigations on this virus. © 2012 Elsevier Ltd.
DescriptionSan Román, Beatriz et al.
Publisher version (URL)http://dx.doi.org/10.1016/j.vaccine.2012.01.081
Identifiersdoi: 10.1016/j.vaccine.2012.01.081
issn: 0264-410X
Appears in Collections:(IDAB) Artículos
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