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| Título: | Small ruminant lentivirus genotype B and E interaction: Evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain |
Autor: | Bertolotti, Luigi; Reina, Ramsés CSIC ORCID ; Rosati, Sergio | Fecha de publicación: | 12-abr-2013 | Editor: | Elsevier | Citación: | Veterinary Microbiology 163(1-2): 33-41 (2013) | Resumen: | Live attenuated vaccines provide the most consistent protective immunity in experimental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naïve animals and appear to limit the spread of histological lesions to the contralateral joints. © 2012 Elsevier B.V. | Descripción: | Bertolotti, Luigi et al. | URI: | http://hdl.handle.net/10261/86693 | DOI: | 10.1016/j.vetmic.2012.12.004 | Identificadores: | doi: 10.1016/j.vetmic.2012.12.004 issn: 0378-1135 |
| Aparece en las colecciones: | (IDAB) Artículos |
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