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Acute and Chronic Disease Associated with Naturally Occurring T-2 Mycotoxicosis in Sheep

AuthorsFerreras, Mª del Carmen ; Benavides, Julio ; García Pariente, C.; Delgado, L. ; Fuertes, M. ; Muñoz, María; García Marín, Juan Francisco ; Pérez Pérez, Valentín
T-2 toxicosis
Issue Date2013
CitationJournal of Comparative Pathology 148 (2-3): 236-242 (2013)
AbstractA flock of approximately 1,000 sheep were exposed intermittently to food contaminated with T-2 toxin (T-2), a potent type-A trichothecene mycotoxin produced primarily by Fusarium sporotrichioides and Fusarium poae. In the acute stage of the intoxication, affected sheep developed anorexia, decreased water consumption, ruminal atony, soft faeces and apathy. One hundred and ninety of the exposed sheep died. The main gross lesions observed in animals dying during the acute disease were rumenitis and ulcerative abomasitis, depletion of lymphocytes in lymphoid organs, necrosis of the exocrine pancreas, myocarditis and intense oedema of the skin and brain. Sheep developing the chronic stage of disease showed weight loss and reproductive inefficiency and the main pathological features observed in animals dying during this stage were gastrointestinal inflammation, myocardial fibrosis and necrotic and suppurative lesions in the oral cavity. Opportunistic infections (e.g. mycotic mastitis or parasitic pneumonia) were also identified in these animals. Increased serum concentrations of lactate dehydrogenase and creatine kinase were observed, most likely related to heart lesions. T-2 toxins were detected in all samples of the diet of these animals that were analyzed. The changes in the sheep reported here are similar to those described previously in experimental studies. Lesions observed in the present animals suggest an additional cardiotoxic effect of T-2 in sheep.
Description7 páginas, 2 figuras.
Publisher version (URL)http://dx.doi.org/10.1016/j.jcpa.2012.05.016
Appears in Collections:(IGM) Artículos
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