English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/86324
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic activity

AuthorsDíaz-Urrua, Christian A.; Olea-Azar, Claudio A.; Zapata, Gerald A.; Lapier, Michael; Mura, Francisco; Aguilera-Venegas, Benjamín; Arán, Vicente J. ; López-Múñoz, Rodrigo A.; Maya, Juan D.
Issue Date2012
PublisherPergamon Press
CitationSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 95: 670- 678 (2012)
AbstractA series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic voltammetry were characterized by electron spin resonance spectroscopy (ESR) and their spectral lines were explained and analyzed using simulated spectra. In addition, we examined the interaction between radical species generated from nitroindazole derivatives and glutathione (GSH). Biological assays such as activity against Trypanosoma cruzi and cytotoxicity against macrophages were carried out. Finally, spin trapping and molecular modeling studies were also done in order to elucidate the potentials action mechanisms involved in the trypanocidal activity. © 2012 Elsevier B.V. All rights reserved.
Identifiersdoi: 10.1016/j.saa.2012.04.076
issn: 1386-1425
e-issn: 1873-3557
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.