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Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modeling of some basic interactions

AuthorsMurado García, Miguel Anxo ; Prieto, Miguel Ángel
KeywordsDose-response analysis
Two effectors
Simulation and modeling
Interaction types
Issue Date2013
PublisherPublic Library of Science
CitationPLoS ONE 8(4): e61391 (2013)
AbstractIn systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA). Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of the interactions that are possible in the system. In addition, these are often applied in such a way that they produce insufficient descriptions of the problem that raises them, frequent inconclusive cases and doubtful decisions. In this work a generative approach is attempted, starting from some simple mechanisms that shows the response of an elementary biological entity to an effector agent. A set of simulations is formulated next through an equally simple system of logical rules, and several families of virtual responses are thus generated. These families include typical responses of IA and CA modes of action, other ones not less probable from a physiological point of view, and even other derived from common and expectable forms of interactions. The analysis of these responses enabled, firstly, to relate some phenomenological regularities with some general mechanistic principles, and to detect several causes by which the IA-CA dualism is necessarily ambiguous. Secondly, it allowed to identify different forms of synergy and antagonism that contribute to explain some controversial aspects of these notions. Finally, it led to propose two sets of explicit algebraic equations which describe accurately a wide diversity of possible and realistic responses
Description21 páginas, 6 tablas, 12 figuras
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0061391
Appears in Collections:(IIM) Artículos
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