Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/83980
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors |
Autor: | García-Esquinas, Esther; Pérez-Gómez, Beatriz; Fernández-Navarro, Pablo; Fernández Martín, Mario Antonio ; Paz, Concha de; Pérez-Meixeira, Ana M; Gil, Elisa; Iriso, Andrés; Sanz, Juan C.; Astray, Jenaro; Cisneros, Margot; Santos, Amparo de; Asensio, Ángel; García-Sagredo, José M; García, José F; Vioque, Jesús; López-Abente, Gonzalo; Pollán, Marina; González Carlos, María José CSIC ORCID ; Martínez, Mercedes; Aragonés, Nuria | Fecha de publicación: | 12-sep-2013 | Editor: | BioMed Central | Citación: | BMC Public Health. 2013 Sep 12;13(1):841 | Resumen: | Abstract Background In Spain, few studies have evaluated prenatal exposure to heavy metals. The objective of this study was to describe lead, mercury and cadmium concentrations in blood from a sample of newborn–mother-father trios, as well as to investigate the association between metals in cord blood and parental variables. We also explored the relationship between cord blood metal concentrations and child characteristics at birth. Methods Metal correlations among family members were assessed using Spearman Rank Correlation Coefficient. Linear regression was used to explore the association between parental variables and log-transformed cord blood lead and cord blood mercury concentrations. In the case of cadmium, tobit regression was used due to the existence of samples below the detection limit. The association between cord blood metal concentrations and child characteristics at birth was evaluated using linear regression. Results Geometric means for lead, mercury and cadmium were 14.09 μg/L, 6.72 μg/L and 0.27 μg/L in newborns; 19.80 μg/L, 3.90 μg/L and 0.53 μg/L in pregnant women; and 33.00 μg/L, 5.38 μg/L and 0.49 μg/L in men. Positive correlations were found between metal concentrations among members of the trio. Lead and cadmium concentrations were 15% and 22% higher in newborns from mothers who smoked during pregnancy, while mercury concentrations were 25% higher in newborns from mothers with greater fish intake. Cord-blood lead levels showed seasonal periodicity, with lower concentrations observed in winter. Cord blood cadmium concentrations over 0.29 μg/L were associated with lower 1-minute and 5-minute Apgar scores. Conclusions These results reinforce the need to establish biomonitoring programs in Spain, and provide support for tobacco smoke and fish consumption as important preventable sources of heavy metal exposure in newborns. Additionally, our findings support the hypothesis that cadmium exposure might be deleterious to fetal development. | URI: | http://hdl.handle.net/10261/83980 | Identificadores: | http://dx.doi.org/10.1186/1471-2458-13-841 |
Aparece en las colecciones: | (IQOG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1471-2458-13-841.xml | 180,71 kB | XML | Visualizar/Abrir | |
1471-2458-13-841.pdf | 220,45 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
353
checked on 23-abr-2024
Download(s)
724
checked on 23-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.