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IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling

AuthorsCosta, M. M. ; Saraceni, Paolo R. ; Forn-Cuni, Gabriel ; Dios, S. ; Romero Jódar, Alejandro ; Figueras Huerta, Antonio ; Novoa, Beatriz
Issue Date2013
CitationDevelopmental and Comparative Immunology 41(4): 746-755 (2013)
AbstractIL-22 plays a role in various disorders in mammals, including mucosal-associated infections and inflammatory diseases. No functional IL-22 studies have been conducted on non-mammals to date. In this study, recombinant IL-22 (rIL-22) from turbot was produced to investigate its effects as a bioactive molecule. The expression of several pro-inflammatory cytokines was increased after rIL-22 treatment and reduced by pre-treatment with a JAK/STAT inhibitor. The involvement of the PI3K pathway in IL-22 induction was demonstrated. rIL-22 reduced the mortality in Aeromonas salmonicida-infected turbot, while higher Aeromonas hydrophila- or LPS-induced mortality was observed when IL-22 was blocked in zebrafish embryos. IL-22 knockdown increased pro-inflammatory cytokine expression in bacteria-stimulated fish. In zebrafish, IL-22 expression was detected primarily in the myeloid innate linage. It was found during early developmental stages when the adaptive immune response is not yet functional and in rag1−/− fish that lack an adaptive immune system. Our results clarify the conserved role of IL-22 in lower vertebrates. We suggest for the first time that IL-22 constitutes a key regulator of inflammatory homeostasis even in distant species such as teleosts, which diverged from mammals more than 350 million years ago.
Description10 páginas, 5 figuras, 1 tabla
Publisher version (URL)http://dx.doi.org/10.1016/j.dci.2013.08.021
Appears in Collections:(IIM) Artículos
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