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Structure and thermodynamical properties of metformin salicylate

AuthorsPérez-Fernández, Ruth ; Fresno, Nieves ; Goya, Pilar ; Elguero, José ; Menéndez-Taboada, L.; García-Granda, Santiago ; Marco, Carlos
Issue Date2013
PublisherAmerican Chemical Society
CitationCrystal Growth and Design 13(4): 1780-1785 (2013)
AbstractThe behavior under thermal conditions of the cocrystal formed by metformin and salicylic acid was studied by DSC, crystallography (single-crystal), and powder diffraction (WAXS). Metformin salicylate crystallizes in space group P21/c, with the salicylate anion showing a planar structure, stabilized by strong intramolecular hydrogen bonds. The more flexible metformin cations link through the oxygen atoms of salicylate, forming a dense hydrogen-bonding network. The compound exists initially as a salt, metformin salicylate, but after melting and cooling, it is transformed into a glass form that crystallizes and melts again, showing different behaviors depending on the heating rate. © 2013 American Chemical Society.
Identifiersdoi: 10.1021/cg400150f
issn: 1528-7483
e-issn: 1528-7505
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