Microwave-assisted selective 5′-O-trityl protection of inosine derivatives

Abstract

The efficient microwave-assisted synthesis of 5′-O-trityl inosine derivatives is described. The reported protocol allows the protection of inosine derivatives in significantly higher yields and shorter reaction times than the standard thermal conditions. This procedure is particularly suitable for modified inosines where the 5′-OH is sterically hindered (i.e. 8-bromoinosine). © Georg Thieme Verlag Stuttgart.