Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/82325
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study |
Autor: | Pigeyre, M.; Bokor, S.; Romon, M.; Gottrand, Frederic; Gilbert, Chantal C.; Valtueña, J.; Gómez-Martínez, Sonia CSIC ORCID; Amouyel, Philippe; Dallongeville, Jean; Meirhaeghe, Aline; Moreno, Luis A. | Fecha de publicación: | 2010 | Editor: | Nature Publishing Group | Citación: | International Journal of Obesity 34: 478- 486 (2010) | Resumen: | Objective:Neuromedin B (NMB) is a bombesin-like peptide, which inhibits food intake and modulates stress-related behaviour. An NMB gene polymorphism (P73T) has been earlier associated with obesity and abnormal eating behaviour in adults.Methods:The association between four NMB polymorphisms and obesity-related phenotypes was investigated in the Healthy Lifestyle in Europe by Nutrition in Adolescence cross-sectional study (n1144, 12-17-year-old European adolescents). This population was genotyped for the NMB rs1107179, rs17598561, rs3809508 and rs1051168 (P73T) polymorphisms. Obesity was defined according to Cole et al. (BMJ 2000; 320:1240-1243) criteria; eating behaviour was assessed by the Eating Behaviour and Weight Problems Inventory for Children (EWI-C) and the food choices and preferences questionnaires. Familial socioeconomic status (SES) was assessed through the parents educational level.Results:Only the genotype distribution of rs3809508 differed according to obesity status, as the TT genotype was more frequent in obese than in non-obese adolescents (8.6% vs 3.1%, P=0.05; adjusted odds ratio for obesity (95% confidence interval): 2.85 (1.11-7.31), P=0.03). Moreover, TT subjects had higher body mass index (22.8±4.4 kg m-2 vs 21.33.7 kg m -2, P=0.02), waist circumference (75.8±9.7 cm vs 72.2±9.3 cm, P=0.006), waist-to-hip ratio (0.84±0.14 vs 0.79±0.07, P<0.0001) and waist-to-height ratio (0.47±0.06 vs 0.44±0.55, P=0.002) than C allele carriers. The effects of this single nucleotide polymorphism on all anthropometric values were influenced by the maternal SES, in that a low maternal educational level aggravated the phenotype of adolescents carrying the TT genotype (interactions: P<0.02). No association with EWI-C scores was found, although sweet craving was a more frequent cause of between-meal food intake in TT subjects than in C allele carriers (24.3% vs 9.2%, P=0.01).Conclusion:In European adolescents, the TT genotype of the NMB rs3809508 polymorphism was associated with a higher risk of obesity. Moreover, the effects of this polymorphism on anthropometric values were influenced by the maternal educational level. © 2010 Macmillan Publishers Limited All rights reserved. | URI: | http://hdl.handle.net/10261/82325 | DOI: | 10.1038/ijo.2009.260 | Identificadores: | doi: 10.1038/ijo.2009.260 issn: 0307-0565 |
Aparece en las colecciones: | (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
18
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
17
checked on 21-feb-2024
Page view(s)
374
checked on 27-mar-2024
Download(s)
102
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.