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Título: | Obesity susceptibility loci on body mass index and weight loss in spanish adolescents after a lifestyle intervention |
Autor: | Moleres, A.; Rendo-Urteaga, T.; Zuleta, A.; Marcos, Ascensión CSIC ORCID; Campoy, Cristina; Garagorri, Jesús M.; Martínez, J. Alfredo; Azcona, Cristina; Martí, Amelia | Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | Journal of Pediatrics 161: 466- 470.e2 (2012) | Resumen: | Objective: To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents. Study design: Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes. Results: At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS. Conclusions: The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention. © 2012 Mosby, Inc. | URI: | http://hdl.handle.net/10261/81995 | DOI: | 10.1016/j.jpeds.2012.04.004 | Identificadores: | doi: 10.1016/j.jpeds.2012.04.004 issn: 0022-3476 |
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