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Título: | Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype? |
Autor: | Peinado, Héctor; Olmeda, David CSIC ORCID; Cano, Amparo CSIC | Fecha de publicación: | 2007 | Editor: | Nature Publishing Group | Citación: | Nature Reviews Cancer 7(6): 415-428 (2007) | Resumen: | The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications. © 2007 Nature Publishing Group. | URI: | http://hdl.handle.net/10261/81769 | DOI: | 10.1038/nrc2131 | Identificadores: | doi: 10.1038/nrc2131 issn: 1474-175X e-issn: 1474-1768 |
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