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A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum

AuthorsQuignodon, L.; Grijota Martínez, María del Carmen; Flamant, Frédéric
Issue Date2007
PublisherSociety for Endocrinology
CitationJournal of Molecular Endocrinology 39(1): 17-28 (2007)
AbstractThyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8-/- mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation. © 2007 Society for Endocrinology.
Identifiersdoi: 10.1677/JME-06-0054
issn: 0952-5041
e-issn: 1479-6813
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