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Título: | A convenient and efficient synthesis of the first (nitroimidazolyl)succinic esters and their diacids |
Autor: | Pacheco-Torres, Jesús CSIC ORCID ; Pérez-Mayoral, Elena; Soriano, Elena CSIC; López-Larrubia, Pilar CSIC ORCID; Ouari, Olivier; Cerdán, Sebastián CSIC ORCID; Ballesteros, Paloma CSIC ORCID | Fecha de publicación: | 2006 | Editor: | Thieme | Citación: | Synthesis 22: 3859-3864 (2006) | Resumen: | We report an easy and efficient synthetic approach to the first series of (nitroimidazolyl)succinic esters and diacids involving the Michael-type addition of the nitroimidazole to the α,β-unsaturated ester. Voltammetric measurements revealed similar redox potentials to those of previous nitroimidazoles used in hypoxia detection. Theoretical calculations were implemented to understand the mechanism of the addition. © Georg Thieme Verlag Stuttgart. | URI: | http://hdl.handle.net/10261/81524 | DOI: | 10.1055/s-2006-950320 | Identificadores: | doi: 10.1055/s-2006-950320 issn: 0039-7881 e-issn: 1437-210X |
Aparece en las colecciones: | (IIBM) Artículos |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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