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In vitro characterization of an Fe8 cluster as potential MRI contrast agent

AuthorsRodríguez, Elisenda ; Roig Serra, Anna ; Molins, Elies ; Arús, Carles; Quintero, María Rosa; Cabañas, Miquel E.; Cerdán, Sebastián ; López-Larrubia, Pilar ; Sanfeliu, Coral
Issue Date2005
CitationNMR in Biomedicine 18(5): 300-307 (2005)
AbstractThe complex [(tacn)6Fe8 (μ3-O) 2(μ2 -OH)12] Br8·9H2O(Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd-DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd-DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p < 0.05). Phantom studies with T1-weighted MRI at 9.4 T suggest T1 contrast potential for Fe8. That is, up to 5.2 times higher intensity enhancement with respect to that of equimolar Gd-DTPA was obtained with an Fe8 concentration, referred to the whole molecule, of 0.2 mM, for which no toxicity on C6 cells could be detected. No toxic effects on cultured C6 cells were observed up to a concentration of 1 mM Fe8. Copyright © 2005 John Wiley & Sons, Ltd.
Identifiersdoi: 10.1002/nbm.959
issn: 0952-3480
e-issn: 1099-1492
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