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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Espada, Jesús | - |
dc.contributor.author | Peinado, Héctor | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Cano, Amparo | - |
dc.date.accessioned | 2013-08-30T07:36:11Z | - |
dc.date.available | 2013-08-30T07:36:11Z | - |
dc.date.issued | 2005 | - |
dc.identifier | doi: 10.1016/j.yexcr.2005.01.009 | - |
dc.identifier | issn: 0014-4827 | - |
dc.identifier | e-issn: 1090-2422 | - |
dc.identifier.citation | Experimental Cell Research 305(2): 409-417 (2005) | - |
dc.identifier.uri | http://hdl.handle.net/10261/81159 | - |
dc.description.abstract | Class IA phosphoinositide 3-OH kinases (PI3K) are lipid kinases composed of catalytic and regulatory subunits. These lipid kinases can regulate the metabolic stability and signaling activity of β-catenin, a central component of the E-cadherin/catenin cell-cell adhesion complex, and of the Wnt signaling pathway. This regulation occurs at the level of glycogen synthase kinase 3 (GSK3), a serine/threonine kinase that marks β-catenin to enter a destruction pathway. In addition, the regulatory subunit p85α directly binds β-catenin, but the role of this interaction in the context of the lipid kinase regulation of β-catenin signaling is unknown. Here we report that expression of exogenous p85α in mouse keratinocytes increases the metabolic stability and has a strong synergistic effect on the transcriptional activity of β-catenin. Both effects are associated to the formation of β-catenin/p85α and inhibition of β-catenin/APC complexes and are independent of GSK3 and PI3K activities. These findings suggest that p85α can act as a direct metabolic regulator of β-catenin activity. © 2005 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | Supported by grants from the Spanish Ministry of Science and Technology (SAF01-02819) and Instituto de Salud Carlos III (FIS03 C03/10) to AC. During the realization of this work JE was partly supported by the Comunidad Autónoma de Madrid (CAM) and HP by a fellowship from the Spanish Ministry of Education, Culture and Sports. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Direct metabolic regulation of β-catenin activity by the p85α regulatory subunit of phosphoinositide 3-OH kinase | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.yexcr.2005.01.009 | - |
dc.date.updated | 2013-08-30T07:36:11Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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