Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/80505
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Prognostic role of host cyclooxygenase and cytokine genotypes in a caucasian cohort of patients with gastric adenocarcinoma |
Autor: | García-González, M. Asunción; Nicolás-Pérez, David; Lanas, Ángel; Bujanda, Luis; Carrera, Patricia; Benito, Rafael; Strunk, Mark; Sopeña, Federico; Santolaria, Santos; Piazuelo, Elena; Jiménez, Pilar; Campo, Rafael; Espinel, Jesús; Manzano, Marisa; Geijo, Fernando; Pellisé, María; González-Huix, Ferran; Espinós, Jorge; Zaballa, Manuel; Tito, Llucia; Barranco, Luis; Pazo, Roberto; Quintero, Enrique | Fecha de publicación: | 2012 | Editor: | Public Library of Science | Citación: | PLoS ONE 7(9): e46179 (2012) | Resumen: | Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI:2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95%CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. Conclusions: Our results show that, in our population, the panel of selected pro- and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma. © 2012 García-González et al. | URI: | http://hdl.handle.net/10261/80505 | DOI: | 10.1371/journal.pone.0046179 | Identificadores: | doi: 10.1371/journal.pone.0046179 issn: 1932-6203 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Prognostic Role.pdf | 727,26 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 15-abr-2024
SCOPUSTM
Citations
12
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
12
checked on 22-feb-2024
Page view(s)
358
checked on 18-abr-2024
Download(s)
352
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.