Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/8025
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1

AutorJiménez-Mateos, Eva María; Wandosell, Francisco CSIC ORCID ; Reiner, Orly; Ávila, Jesús CSIC ORCID ; González-Billault, Christian
Palabras claveLissencephaly-related protein 1 (LIS1)
Dynein
Microtubule-associated protein 1B (MAP1B)
Microtubule
Transgenic mouse
Fecha de publicación11-mar-2005
EditorBiochemical Society
CitaciónBiochemical Journal 389: 333–341 (2005)
ResumenFor neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1 (lissencephaly-related protein 1), interact with one another and participate in neuronal migration. Our results indicate that, in hippocampal neurons, MAP1B and LIS1 co-localize, associate and interact with each another. The interaction between these two MAPs is regulated by the phosphorylation of MAP1B. Furthermore, this interaction interferes with the association between LIS1 and the microtubule-dependent molecular motor, dynein. Clearly, the differential binding of these cytoskeletal proteins could regulate the functions attributed to the LIS1–dynein complex, including those related to extension of the neural processes necessary for neuronal migration.
Versión del editorhttp://dx.doi.org/10.1042/BJ20050244
URIhttp://hdl.handle.net/10261/8025
DOI10.1042/BJ20050244
ISSN0264-6021
E-ISSN1470-8728
Aparece en las colecciones: (CBM) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
EMJimémez-Mateos_BiochemJ_333.pdf543,37 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

14
checked on 29-mar-2024

SCOPUSTM   
Citations

31
checked on 21-mar-2024

WEB OF SCIENCETM
Citations

28
checked on 28-feb-2024

Page view(s)

394
checked on 29-mar-2024

Download(s)

233
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.