Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/80114
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Medina, Gema | - |
dc.contributor.author | Hernández, Arturo | - |
dc.contributor.author | Calvo, Rosa M. | - |
dc.contributor.author | Martin, Eva | - |
dc.contributor.author | Obregón, María Jesús | - |
dc.date.accessioned | 2013-07-24T07:58:04Z | - |
dc.date.available | 2013-07-24T07:58:04Z | - |
dc.date.issued | 2003 | - |
dc.identifier | doi: 10.1007/s00018-003-3158-9 | - |
dc.identifier | issn: 1420-682X | - |
dc.identifier | e-issn: 1420-9071 | - |
dc.identifier.citation | Cellular and Molecular Life Sciences 60(9): 1957-1967 (2003) | - |
dc.identifier.uri | http://hdl.handle.net/10261/80114 | - |
dc.description.abstract | Triiodothyroacetic acid (TRIAC) is a triiodothyronine (T3) metabolite with high affinity for T3 nuclear receptors. We compared the thermogenic action of TRIAC versus T3 in brown adipocytes, by studying target genes known to mediate thermogenic action: uncoupling protein 1 (UCP-1), a marker of brown adipocytes, and type II-5′deiodinase (D2), which provides the T3 required for thermogenesis. TRIAC is 10-50 times more potent than T3 at increasing the adrenergic induction of UCP-1 mRNA and D2 activities. TRIAC action on UCP-1 is exerted at the transcriptional level. In the presence of an adrenergic stimulus, TRIAC is also more potent than T3, inducing lipoprotein lipase mRNA and 5 deiodinase (D3) activity and mRNA. Maximal effects occur at very low concentrations (0.2 nM). The greater potency of TRIAC is not due to preferential cellular or nuclear uptake. Therefore, TRIAC is a potent thermogenic agent that might increase energy expenditure and regulate T3 production in brown adipocytes. | - |
dc.description.sponsorship | This work was supported by research grants PB 95-0097 from Promoción General del Conocimiento (PGC) (Spain), FISS 94/0274 and 99/0813 from Fondo de Investigaciones Sanitarias (FIS), CAM 08.6/0030/1998 from Comunidad de Madrid (CAM) (Spain) and SAF2001-2243 from PN (Spain). | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.rights | closedAccess | - |
dc.title | Potent thermogenic action of triiodothyroacetic acid in brown adipocytes | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s00018-003-3158-9 | - |
dc.date.updated | 2013-07-24T07:58:04Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
24
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
19
checked on 24-feb-2024
Page view(s)
342
checked on 24-abr-2024
Download(s)
123
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.