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Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Terpenoids from Maytenus Species

AutorKennedy, M. L.; Llanos, G. G.; Castanys, Santiago; Gamarro, Francisco; Bazzocchi, I. L.; Jiménez, I. A.
Fecha de publicación2011
EditorJohn Wiley & Sons
CitaciónChemistry and Biodiversity 8: 2291- 2298 (2011)
ResumenThe phytochemical analysis of the root bark extracts of the Chilean Maytenus, M. chubutensis, and M. magellanica (Celastraceae), led to the isolation of one phenolic nortriterpene, 1, and one diterpene with a nor-ent-kaurene skeleton, 2. In addition, four known compounds were isolated, among which compound 3 has been isolated for the first time from a natural source. Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR (COSY, ROESY, HSQC, and HMBC) experiments, comparison with data reported in the literature, and chemical correlations. The isolated compounds were assayed for their reversal activity against a multidrug-resistant Leishmania tropica line, overexpressing a P-glycoprotein related transporter. Compound 1 showed moderate multidrug-resistance reversal activity. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
DescripciónPreprint. Versión definitiva publicada con el título "Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line" DOI: 10.1002/cbdv.201000356
Identificadoresdoi: 10.1002/cbdv.201000356
issn: 1612-1872
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