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dc.contributor.authorRobles, Maria S.-
dc.contributor.authorLeonardo, Esther-
dc.contributor.authorCriado, Luis M.-
dc.contributor.authorIzquierdo, Manuel-
dc.contributor.authorMartínez-A, Carlos-
dc.date.accessioned2013-07-22T12:44:59Z-
dc.date.available2013-07-22T12:44:59Z-
dc.date.issued2002-
dc.identifierissn: 0022-1767-
dc.identifiere-issn: 1550-6606-
dc.identifier.citationJournal of Immunology 168(4): 1770-1779 (2002)-
dc.identifier.urihttp://hdl.handle.net/10261/80042-
dc.description.abstractThe inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-κB and reduced cytoplasmic levels of its inhibitor, IκBα. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.-
dc.description.sponsorshipThis work was supported by Grants from the Dirección General de Investigación, Ministry of Science and Technology. The Department of Immunology and Oncology was founded and is supported by the Spanish Council for Scientific Research and the Pharmacia Corporation. M.S.R. received fellowships from the Consejo Superior de Investigaciones Científicas/Pharmacia and the Regional Government of Madrid (Comunidad Autónoma de Madrid).-
dc.language.isoeng-
dc.publisherAmerican Association of Immunologists-
dc.rightsclosedAccess-
dc.titleInhibitor of apoptosis protein from ORGYIA pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes-
dc.typeartículo-
dc.date.updated2013-07-22T12:44:59Z-
dc.description.versionPeer Reviewed-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderComunidad de Madrid-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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