Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/80042
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Inhibitor of apoptosis protein from ORGYIA pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes |
Autor: | Robles, Maria S.; Leonardo, Esther; Criado, Luis M.; Izquierdo, Manuel CSIC ORCID ; Martínez-A, Carlos CSIC ORCID | Fecha de publicación: | 2002 | Editor: | American Association of Immunologists | Citación: | Journal of Immunology 168(4): 1770-1779 (2002) | Resumen: | The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-κB and reduced cytoplasmic levels of its inhibitor, IκBα. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo. | URI: | http://hdl.handle.net/10261/80042 | Identificadores: | issn: 0022-1767 e-issn: 1550-6606 |
Aparece en las colecciones: | (IBGM) Artículos (CNB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
324
checked on 19-mar-2024
Download(s)
93
checked on 19-mar-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.