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Title

Inhibitor of apoptosis protein from ORGYIA pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes

AuthorsRobles, Maria S.; Leonardo, Esther; Criado, Luis M.; Izquierdo, Manuel ; Martínez-A, Carlos
Issue Date2002
PublisherAmerican Association of Immunologists
CitationJournal of Immunology 168(4): 1770-1779 (2002)
AbstractThe inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-κB and reduced cytoplasmic levels of its inhibitor, IκBα. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.
URIhttp://hdl.handle.net/10261/80042
Identifiersissn: 0022-1767
e-issn: 1550-6606
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