English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/79724
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Role of diffusible and transcription factors in inner ear development: implications in regeneration

AuthorsFrago, Laura M.; Camarero, Guadalupe ; Cañon, Susana; Pañeda, Covadonga; Sanz, Carmen; León, Yolanda; Giráldez, Fernando; Varela-Nieto, Isabel
Issue Date2000
PublisherUniversidad de Murcia
CitationHistology and Histopathology 15(2): 657-666 (2000)
AbstractOrganogenesis involves a dynamic balance of the mechanisms regulating cell division, differentiation and death. The development of the chicken embryo inner ear offers a well-characterised model at the morphological level to study which signals are implicated in the modulation of cellular activation and commitment. The early developmental decisions that control the origin of the inner ear elements are just beginning to be identified by complementary in vivo and in vitro studies. Insulin-like growth factor-I (IGF-I) and nerve growth factor (NGF) are among the best characterised diffusible factors acting during inner ear development. Although the cellular actions of these factors are beginning to be understood, the signalling pathways triggered by them still remain largely unknown. In this context, viral vehicles can be used to deliver genes and then analyse their functional roles during inner ear development. A model is proposed where the actions of IGF-I and NGF contribute to the combinatorial expression of Jun and Fos family members in particular domains of the otic vesicle. Some of these mechanisms may be also implicated in otic regeneration.
Publisher version (URL)http://www.hh.um.es/Abstracts/Vol_15/15_2/15_2_37.htm
URIhttp://hdl.handle.net/10261/79724
Identifiersissn: 0213-3911
e-issn: 1699-5848
Appears in Collections:(IIBM) Artículos
(IBGM) Artículos
Files in This Item:
File Description SizeFormat 
Role of diffusible.pdf5,58 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.