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1,25-dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells

AuthorsGonzález-Sancho, José Manuel ; Álvarez-Dolado, Manuel ; Muñoz Terol, Alberto
Issue Date1998
CitationFEBS Letters 426(2): 225-228 (1998)
AbstractTenascin-C is an extracellular matrix protein with growth-, invasion- and angiogenesis-promoting activities. Tenasein-C is upregulated in breast carcinoma and stromal cells, and in many other cell types during tumorigenesis. We demonstrate that tenascin-C RNA expression is inhibited by 1,25-dihydroxyvitamin D3 (1,25-D3) in a variety of mouse and human mammary epithelial cell lines exhibiting normal or malignant phenotype. In EpH4 cells, the inhibition is maximum 24 h after 1,25-D3 treatment and correlates with a dose-dependent reduction in the synthesis of tenascin-C protein. Furthermore, 1,25-D3 also abolishes the induction of tenascin-C by serum or the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate. The inhibition of tenascin-C expression may be relevant for the anticancer activity of 1,25- D3.
Identifiersdoi: 10.1016/S0014-5793(98)00348-2
issn: 0014-5793
e-issn: 1873-3468
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