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Title

Activation of the HIV-1 long terminal repeat by nerve growth factor

AuthorsRecio, Juan A.; Aranda, Ana
Issue Date1997
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 272(43): 26807-26810 (1997)
AbstractThe brain is an important target for the human immunodeficiency virus type 1 (HIV-1). We show here that nerve growth factor (NGF), which induces neuronal differentiation and survival, causes a strong activation of the HIV- 1 long terminal repeat by a Ras/Raf-dependent mechanism in PC12 cells. Mutation of the κB sequences contained within the long terminal repeat reduces NGF-mediated stimulation. NGF does not activate NF-κB in PC12 cells, but rather increases binding of other nuclear factors to the κB sequences. Furthermore, a nuclear receptor response element contributes to the stimulatory effect of NGF. The retinoids receptors have been identified as components of the nuclear binding to the nuclear receptor response element in NGF-treated PC12 cells. These results reveal the importance of neurotrophins and nuclear receptor signaling pathways as specific activators of HIV-1 gene expression in neural cells.
URIhttp://hdl.handle.net/10261/79218
DOI10.1074/jbc.272.43.26807
Identifiersdoi: 10.1074/jbc.272.43.26807
issn: 0021-9258
e-issn: 1083-351X
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