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Título: | Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide |
Autor: | Cano, Carolina CSIC; Páez, Juan A. CSIC ORCID; Goya, Pilar CSIC ORCID; Serrano, A.; Pavón, Javier; Rodríguez de Fonseca, Fernando; Suardíaz, M.; Martín, M. Isabel CSIC | Fecha de publicación: | 2009 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry 44: 4889- 4895 (2009) | Resumen: | Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimimetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by -CH2NHSO2NH-R considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive. © 2009. | URI: | http://hdl.handle.net/10261/79157 | DOI: | 10.1016/j.ejmech.2009.08.003 | Identificadores: | doi: 10.1016/j.ejmech.2009.08.003 issn: 0223-5234 e-issn: 1768-3254 |
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