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Título

Molecular analysis of chromosomh 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors

AutorBello, M. Josefa; Saez-Castresana, Javier; Pestaña, Ángel ; Rey, Juan A.
Fecha de publicación1994
EditorWiley-Blackwell
CitaciónInternational Journal of Cancer 57(2): 172-175 (1994)
ResumenAlterations of the short arm of chromosome I are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of Ip36-p32 region characterize at least the higher-grade tumors, glioblastoma multiforme. Molecular analysis of tumor-derived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome I-specific DNA probes showed LOH in 16 tumors. Allelic losses on I p were primarily restricted to glioblastoma multiforme (2/11) and to tumors with a major oligodendroglial component: grade 11 oligodendrogliomas (6/6), grade 111 anaplastic oligodendrogliomas (5/6) and grade II-III mixed oligo-astrocytomas (2/3). Losses for Iq markers were detected in only I tumor (glioblastoma multiforme). Our data suggest that anomalies of Ip primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor-suppressor gene on Ip36-p32 is involved in the development of brain tumors with oligodendroglial differentiation.
URIhttp://hdl.handle.net/10261/78884
DOI10.1002/ijc.2910570207
Identificadoresdoi: 10.1002/ijc.2910570207
issn: 0020-7136
e-issn: 1097-0215
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